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English
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2023
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Amrutkar, Manoj; Berg, Kjersti; Balto, Aina; Skilbrei, Miguel Garcia; Finstadsveen, Anette Vefferstad; Aasrum, Monica; Gladhaug, Ivar Prydz; Verbeke, Caroline Sophie. Pancreatic stellate cell-induced gemcitabine resistance in pancreatic cancer is associated with LDHA- and MCT4-mediated enhanced glycolysis. Cancer Cell International 2023 ;Volum 23. s. 1-17 UiO OUS
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2. |
Li, Yuchuan; Amrutkar, Manoj; Finstadsveen, Anette V.; Dalen, Knut Tomas; Verbeke, Caroline Sophie; Gladhaug, Ivar Prydz. Fatty acids abrogate the growth-suppressive effects induced by inhibition of cholesterol flux in pancreatic cancer cells. Cancer Cell International 2023 ;Volum 23. UiO OUS
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3. |
Resell, Mathilde Victoria; Rabben, Hanne-Line; Amrutkar, Manoj; Hagen, Lars; Batra, Surinder K.; Verbeke, Caroline Sophie; Wang, Timothy Cragin; Chen, Duan; Zhao, Chun Mei. Mo1138 COMPARATIVE PROTEOMICS REVEALS TRANSLATIONAL POTENTIAL OF TARGETS FOR PANCREATIC DUCTAL ADENOCARCINOMA. Gastroenterology 2023 ;Volum 164.(6) Suppl. AGA Abstracts s. S-771-S-771 NTNU UiO OUS
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2022
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Amrutkar, Manoj; Verbeke, Caroline Sophie; Vefferstad, Anette; Dorg, Linda Trobe; Labori, Knut Jørgen; Gladhaug, Ivar Prydz. Neoadjuvant chemotherapy is associated with an altered metabolic profile and increased cancer stemness in patients with pancreatic ductal adenocarcinoma. Molecular Oncology 2022 ;Volum 17.(1) s. 59-81 OUS UiO
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2021
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Amrutkar, Manoj; Gladhaug, Ivar Prydz. Stellate cells aid growth‐permissive metabolic reprogramming and promote gemcitabine chemoresistance in pancreatic cancer. Cancers 2021 ;Volum 13:601.(4) s. 1-21 OUS UiO
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6. |
Caputo, Mara; Kurhe, Yeshwant; Kumari, Sima; Cansby, Emmelie; Amrutkar, Manoj; Scandalis, Eli; Booten, Sheri L.; Ståhlman, Marcus; Borén, Jan; Marschall, Hanns-Ulrich; Aghajan, Mariam; Mahlapuu, Margit. Silencing of STE20-type kinase MST3 in mice with antisense oligonucleotide treatment ameliorates diet-induced nonalcoholic fatty liver disease. The FASEB Journal 2021 ;Volum 35.(5) s. - UiO
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7. |
Santha, Petra; Lenggenhager, Daniela; Vefferstad, Anette; Dorg, Linda Trobe; Tøndel, Kristin; Amrutkar, Manoj; Gladhaug, Ivar Prydz; Verbeke, Caroline Sophie. Morphological heterogeneity in pancreatic cancer reflects structural and functional divergence. Cancers 2021 ;Volum 13.(4) s. - OUS UiO NMBU
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2020
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8. |
Amrutkar, Manoj; Larsen, Emma Kristine; Aasrum, Monica; Finstadsveen, Anette Vefferstad; Andresen, Per Arne; Verbeke, Caroline Sophie; Gladhaug, Ivar Prydz. Establishment and Characterization of Paired Primary Cultures of Human Pancreatic Cancer Cells and Stellate Cells Derived from the Same Tumor. Cells 2020 ;Volum 9:227.(1) s. 1-18 OUS UiO
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9. |
Amrutkar, Manoj; Vethe, Nils Tore; Verbeke, Caroline Sophie; Aasrum, Monica; Vefferstad, Anette; Santha, Petra; Gladhaug, Ivar Prydz. Differential gemcitabine sensitivity in primary human pancreatic cancer cells and paired stellate cells is driven by heterogenous drug uptake and processing. Cancers 2020 ;Volum 12:3628.(12) s. 1-18 UiO OUS
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2019
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10. |
Amrutkar, Manoj; Aasrum, Monica; Verbeke, Caroline Sophie; Gladhaug, Ivar Prydz. Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells. BMC Cancer 2019 ;Volum 19.(596) s. - UiO OUS
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11. |
Cansby, Emmelie; Kulkarni, Nagaraj M; Magnusson, Elin; Kurhe, Yeshwant; Amrutkar, Manoj; Nerstedt, Annika; Ståhlman, Marcus; Sihlbom, Carina; Marschall, Hanns-Ulrich; Borén, Jan; Blüher, Matthias; Mahlapuu, Margit. Protein Kinase MST3 Modulates Lipid Homeostasis in Hepatocytes and Correlates With Nonalcoholic Steatohepatitis in Humans. The FASEB Journal 2019 ;Volum 33.(9) s. 9974-9989 UiO
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12. |
Cansby, Emmelie; Nunez-duran, Esther; Magnusson, Elin; Amrutkar, Manoj; Booten, Sheri L.; Kulkarni, Nagaraj M; Svensson, L. Thomas; Borén, Jan; Marschall, Hanns-Ulrich; Aghajan, Mariam; Mahlapuu, Margit. Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease. Cellular and Molecular Gastroenterology and Hepatology (CMGH) 2019 ;Volum 7.(3) s. 597-618 UiO
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13. |
Lenggenhager, Daniela; Amrutkar, Manoj; Santha, Petra; Aasrum, Monica; Löhr, Johannes-Matthias; Gladhaug, Ivar Prydz; Verbeke, Caroline Sophie. Commonly Used Pancreatic Stellate Cell Cultures Differ Phenotypically and in Their Interactions With Pancreatic Cancer Cells. Cells 2019 ;Volum 8:E23.(1) s. 1-18 OUS UiO
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2018
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14. |
Cansby, Emmelie; Magnusson, Elin; Nunez-duran, Esther; Amrutkar, Manoj; Pedrelli, Matteo; Parini, Paolo; Hoffmann, Jenny; Ståhlman, Marcus; Howell, Brian w.; Marschall, Hanns-Ulrich; Borén, Jan; Mahlapuu, Margit. STK25 Regulates Cardiovascular Disease Progression in a Mouse Model of Hypercholesterolemia. Arteriosclerosis, Thrombosis and Vascular Biology 2018 ;Volum 38.(8) UiO
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15. |
Sutt, Silva; Cansby, Emmelie; Paul, Alexandra; Amrutkar, Manoj; Nunez-duran, Esther; Kulkarni, Nagaraj M; Ståhlman, Marcus; Boren, Jan; Laurencikiene, Jurga; Howell, Brian w.; Enerbäck, Sven; Mahlapuu, Margit. STK25 regulates oxidative capacity and metabolic efficiency in adipose tissue. Journal of Endocrinology 2018 ;Volum 238.(3) s. 187-202 UiO
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2017
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16. |
Amrutkar, Manoj; Gladhaug, Ivar Prydz. Pancreatic cancer chemoresistance to gemcitabine. Cancers 2017 ;Volum 9.(11:157) s. 1-23 UiO OUS
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17. |
Chursa, Urszula; Nunez-duran, Esther; Cansby, Emmelie; Amrutkar, Manoj; Sutt, Silva; Ståhlman, Marcus; Olsson, Britt-marie; Borén, Jan; Johansson, Maria e.; Bäckhed, Fredrik; Johansson, Bengt r.; Sihlbom, Carina; Mahlapuu, Margit. Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal muscle. Diabetologia 2017 ;Volum 60.(3) s. 553-567 UiO
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18. |
Nunez-duran, Esther; Aghajan, Mariam; Amrutkar, Manoj; Sutt, Silva; Cansby, Emmelie; Booten, Sheri l.; Watt, Andrew; Ståhlman, Marcus; Stefan, Norbert; Haring, Hans-ulrich; Staiger, Harald; Borén, Jan; Marschall, Hanns-Ulrich; Mahlapuu, Margit. Serine/Threonine Protein Kinase 25 Antisense Oligonucleotide Treatment Reverses Glucose Intolerance, Insulin Resistance, and Nonalcoholic Fatty Liver Disease in Mice. Hepatology communications. 2017 ;Volum 2.(1) s. 69-83 UiO
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2016
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19. |
Amrutkar, Manoj; Chursa, Urszula; Kern, Matthias; Nunez-duran, Esther; Ståhlman, Marcus; Sutt, Silva; Borén, Jan; Johansson, Bengt r.; Marschall, Hanns-Ulrich; Blüher, Matthias; Mahlapuu, Margit. STK25 is a critical determinant in nonalcoholic steatohepatitis. The FASEB Journal 2016 ;Volum 30.(10) s. 3628-3643 UiO
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20. |
Amrutkar, Manoj; Kern, Matthias; Nunez-duran, Esther; Ståhlman, Marcus; Cansby, Emmelie; Chursa, Urszula; Stenfeldt, Elin; Borén, Jan; Blüher, Matthias; Mahlapuu, Margit. Protein kinase STK25 controls lipid partitioning in hepatocytes and correlates with liver fat content in humans. Diabetologia 2016 ;Volum 59. s. 341-353 UiO
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2015
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21. |
Amrutkar, Manoj; Cansby, Emmelie; Chursa, Urszula; Nunez-duran, Esther; Chanclón, Belén; Ståhlman, Marcus; Friden, Vincent; Mannerås-holm, Louise; Wickman, Anna; Smith, Ulf; Bäckhed, Fredrik; Borén, Jan; Howell, Brian w.; Mahlapuu, Margit. Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model. Diabetes 2015 ;Volum 64. s. 2791-2804 UiO
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22. |
Amrutkar, Manoj; Cansby, Emmelie; Nunez-duran, Esther; Pirazzi, Carlo; Ståhlman, Marcus; Stenfeldt, Elin; Smith, Ulf; Borén, Jan; Mahlapuu, Margit. Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and NASH. The FASEB Journal 2015 ;Volum 29.(4) s. 1564-1576 UiO
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2014
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23. |
Cansby, Emmelie; Nerstedt, Annika; Amrutkar, Manoj; Nunez-duran, Esther; Smith, Ulf; Mahlapuu, Margit. Partial hepatic resistance to IL-6-induced inflammation develops in type 2 diabetic mice, while the anti-inflammatory effect of AMPK is maintained. Molecular and Cellular Endocrinology 2014 ;Volum 393. s. 143-151 UiO
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2013
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24. |
Cansby, Emmelie; Amrutkar, Manoj; Mannerås-holm, Louise; Nerstedt, Annika; Reyahi, Azadeh; Stenfeldt, Elin; Booten, Sheri l.; Carlsson, Peter; Smith, Ulf; Zierath, Juleen r.; Mahlapuu, Margit. Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat diet. The FASEB Journal 2013 ;Volum 27.(9) s. 3660-3671 UiO
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25. |
Nerstedt, Annika; Cansby, Emmelie; Amrutkar, Manoj; Smith, Ulf; Mahlapuu, Margit. Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes. Molecular and Cellular Endocrinology 2013 ;Volum 375. s. 68-78 UiO
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